The rising demand led companies and research groups to follow in the footsteps of plant and animal agriculture and implement new tools to advance traditional breeding into the molecular breeding era. Innovation, technological advancements, and manufacturing technology (not covered in this blog) allowed the aquaculture industry to up-scale, and over the last 20 years, biotechnology and breeding became strongly incorporated into aquaculture.
Biotechnology can identify and combine traits to increase productivity and improve the quality of fish and shellfish. Scientists search for genes that can increase both the production of natural fish growth factors as well as the natural defense compounds marine organisms use to fight microbial infections.
Genetic manipulation (GM) was the main approach for altering genes at the genomic level. The first product to be approved was genetically manipulated salmon. In these salmon varieties, the gene for growth hormones was duplicated, causing an amazing 10-30% increase in growth rate and a reduction in growth time by 50%. Other GM fish were created with disease resistance and improved quality traits. The future of biotechnology applications in aquaculture will include the adoption of the CRISPR/CA9 gene-editing technology. For this to take place, high-resolution assembled genomes are required in addition to scientific research to reveal beneficial changes in the genome of the targeted organism.
Unlike GM, systematic and efficient breeding programs to improve economically important traits in farmed species, were rarely utilized until the last decade. Therefore, the majority of aquaculture production was based on genetically unimproved stocks. In farm animals, the situation is vastly different, namely that practically all terrestrial farm production is based on genetically improved and domesticated populations. This essential difference exists between aquaculture and livestock production in spite of the fact that the basic elements of the breeding theory are the same for fish and shellfish as for farm animals. That said, in the last 20 years, efficient breeding programs were implemented that helped close the gap. Below are the main selective breeding methods used:
- Mass selection was an easy solution to implement, with no need to tag individual fish. From each brood stock, the best-performing fish were selected for breeding of commercial fish. Mass selection was exceptionally efficient in selecting against disease susceptibility where, after infecting the surviving population, fish were used to pass the resistance to the next generation.
- Pedigree-based selection within the family, between family selections or combined. Mapping the relationships and using quantitative genetics to predict the next generation of brood stock with improved performance.
- Marker-assisted selection: identify genomic markers linked to the trait and use them as part of the selection program.
- Genomic selection: genomic prediction models and algorithms improves accuracy in selecting the next generation of enhanced brood stocks. This method brings genetic gain per generation but comes with higher complexity in applying the technology and increased cost.
The genetic improvement obtained in selective breeding programs for fish and shellfish is remarkable and much higher than what has been achieved so far in terrestrial farm animals.
Looking at the future of aquaculture, the industry faces challenges and opportunities:
- Innovation and technological advancements are required to enable sustainable growth.
- Collaboration and partnerships will play an important role in accelerating the speed and scale of production.
- Increased investment and funding will be critical to help implement best-practices and new innovations such as gene editing and advance genomic prediction models like genomic selection.
- Greater collection and utilization of farm data will support smarter decision-making.
- Reduction of ecosystem impacts and new technologies that help integrate aquaculture as part of future life while minimizing any harm to the environment.
- Positive social impact. The aquaculture industry provides a healthier food product and a means of sustainable economic support for people worldwide.
By 2030, about 66% of seafood is predicted to come from aquaculture. Production and selective breeding will become one of the main engines of future growth. On top of traditional breeding methods, companies like NRGene can use its experience and computational abilities to help our partners conduct better breeding through finding genetic markers, improving the accuracy of their genotyping process, reducing the associated costs, and developing and implementing prediction algorithms for improved genetic gain.